Publication:
Knuckle Pigmentation as an Early Cutaneous Sign of Vitamin B12 Deficiency: A Case Report

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorSrivastava, Ankita
dc.contributor.authorChoudhary, Sanjiv
dc.date.accessioned2026-03-26T08:54:38Z
dc.date.available2026-03-26T08:54:38Z
dc.date.issued2020
dc.descriptionAnkita Srivastava Department of Dermatology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India Sanjiv Choudhary Department of Dermatology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India
dc.description.abstractAbstracts: Vitamin B12 deficiency can present with variable hematological, neuropsychiatric, and mucocutaneous changes. Hyperpigmentation, specifically involving the knuckles has been described in vitamin B12 deficiency, but usually,these patients are symptomatic with systemic manifestations like megaloblastic anemia, pancytopenia, or neurological deficits. Here, we are reporting a case of nutritional vitamin B12 deficiency, who presented with isolated knuckle pigmentation and was successfully treated with oral therapy. This case also highlights the importance of recognizing this cutaneous sign as an early marker of vitamin B12 deficiency; thereby enabling the clinician to treat the disease before it leads to irreversible neurological complications.
dc.identifierhttps://doi.org/10.31729/jnma.5048
dc.identifier.urihttps://hdl.handle.net/20.500.14572/5494
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.subjectknuckle pigmentation
dc.subjecttreatment
dc.subjectvitamin B12 deficiency
dc.titleKnuckle Pigmentation as an Early Cutaneous Sign of Vitamin B12 Deficiency: A Case Report
dc.typeArticle
dspace.entity.typePublication
local.article.typeCase Report
oaire.citation.endPage800
oaire.citation.startPage798
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relation.isJournalOfPublicatione6e146a0-0ece-4aba-aa0a-6ccfbd10a12a

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