Publication: Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review
Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Medical Association
Abstract
Abstract:
The cases of coronavirusdisease 2019 in children have been increasing with the ongoing pandemic.The finding suggests children have mild symptoms and a short course of the disease. Angiotensinconverting enzyme-2 mediates entry of the virus into the cell, the combination of virus and ACE2 leads to an increase in activity of angiotensin II, resulting in acute injury to lungs, myocardium and other organs. The infection causes down-regulation of ACE2 expression. The ACE2 plays an important role in the infection progression and clinical characteristics of COVID-19. Works on ACE2 and virus spike protein have future prospects of strategic information on prevention, management as well as vaccine development.
Description
Qian Gao
Xi’an Medical University, Xi’an, China
https://orcid.org/0000-0001-9734-0439
Jing Liu
Xi’an Medical University, Xi’an, China
Zhilong Mu
Children's Hospital of Shaanxi Provincial People's Hospital, 3rd Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an Shanxi, China
Xianpeng Yan
Children's Hospital of Shaanxi Provincial People's Hospital, 3rd Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an Shanxi, China
Jay Narayan Shah
Patan Hospital, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal
http://orcid.org/0000-0003-4781-7096
Fuyong Jiao
Children's Hospital of Shaanxi Provincial People's Hospital, 3rd Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an Shanxi, China
Keywords
children, Coronavirus Disease 2019 (COVID-19), SARS-Cov-2, Angiotensin-Converting Enzyme 2 (ACE2)