Publication:
Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorGao, Qian
dc.contributor.authorLiu, Jing
dc.contributor.authorMu, Zhilong
dc.contributor.authorYan, Xianpeng
dc.contributor.authorShah, Jay Narayan
dc.contributor.authorJiao, Fuyong
dc.date.accessioned2026-03-29T05:07:27Z
dc.date.available2026-03-29T05:07:27Z
dc.date.issued2020
dc.descriptionQian Gao Xi’an Medical University, Xi’an, China https://orcid.org/0000-0001-9734-0439 Jing Liu Xi’an Medical University, Xi’an, China Zhilong Mu Children's Hospital of Shaanxi Provincial People's Hospital, 3rd Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an Shanxi, China Xianpeng Yan Children's Hospital of Shaanxi Provincial People's Hospital, 3rd Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an Shanxi, China Jay Narayan Shah Patan Hospital, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal http://orcid.org/0000-0003-4781-7096 Fuyong Jiao Children's Hospital of Shaanxi Provincial People's Hospital, 3rd Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an Shanxi, China
dc.description.abstractAbstract: The cases of coronavirusdisease 2019 in children have been increasing with the ongoing pandemic.The finding suggests children have mild symptoms and a short course of the disease. Angiotensinconverting enzyme-2 mediates entry of the virus into the cell, the combination of virus and ACE2 leads to an increase in activity of angiotensin II, resulting in acute injury to lungs, myocardium and other organs. The infection causes down-regulation of ACE2 expression. The ACE2 plays an important role in the infection progression and clinical characteristics of COVID-19. Works on ACE2 and virus spike protein have future prospects of strategic information on prevention, management as well as vaccine development.
dc.identifierhttps://doi.org/10.31729/jnma.5436
dc.identifier.urihttps://hdl.handle.net/20.500.14572/5498
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.subjectchildren
dc.subjectCoronavirus Disease 2019 (COVID-19)
dc.subjectSARS-Cov-2
dc.subjectAngiotensin-Converting Enzyme 2 (ACE2)
dc.titleClinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review
dc.typeArticle
dspace.entity.typePublication
local.article.typeReview Article
oaire.citation.endPage819
oaire.citation.startPage813
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relation.isJournalIssueOfPublication.latestForDiscoverya9f65dbb-17ef-4901-b0c4-bfbd61d5a935
relation.isJournalOfPublicatione6e146a0-0ece-4aba-aa0a-6ccfbd10a12a

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