Publication: Adenosine Receptors as Targets for Therapeutic Interven- tion
Date
2013
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu university
Abstract
ABSTRACT
Adenosine receptors are major targets of caffeine, the most commonly consumed
drug in the world. There is growing evidence that they could also be promising
therapeutic targets in a wide range of conditions, including cerebral and cardiac
ischaemic diseases, sleep disorders, immune and inflammatory disorders and
cancer. After more than three decades of medicinal chemistry research, a
considerable number of selective agonists and antagonists of adenosine receptors
have been discovered, and some have been clinically evaluated, although none has
yet received regulatory approval. However, recent advances in the understanding
of the roles of the various adenosine receptor subtypes, and in the development
of selective and potent ligands, as discussed in this review, have brought the goal
of therapeutic application of adenosine receptor modulators considerably closer.
KEYWORDS
Adenosine, asthma, ischaemia/reperfusion injury, Parkinson’s disease, refractory
primary pulmonary hypertension
Description
Suvarna B
Department of Pharmacology
Melaka Manipal Medical College Manipal Campus, Manipal India