Publication: Clinico-epidemiological Profile of Extra Hepatic Portal Vein Obstruction: A Tertiary Care Hospital Based Retrospective Study
Date
2019
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Extra hepatic portal vein obstruction (EHPVO) is a common cause of portal
hypertension in the developing countries (up to 30% of all variceal bleeders) and is
second to cirrhosis in the West (up to 5-10%). Our understanding of the disease is
poor compared with other illnesses.
Objective
To undertake a retrospective study of the clinicoepidemiological profile of Extra
hepatic portal vein obstruction in a tertiary care hospital in eastern Nepal.
Method
All consecutive adult patients whose features were consistent with the diagnosis
of extra hepatic portal vein obstruction from June 2014 to June 2016 were
retrospectively analyzed to explore the various clinico-epidemiological parameters.
Result
A total of 58 patients were enrolled in the study with a median age of 24 years (20.5-
40). Portal vein thrombosis was the most common cause of extrahepatic portal vein
obstruction. Hematemesis followed by melena were the most common presenting
symptoms. All patients had splenomegaly on examination. None of the patients had
clinical, biochemical or radiological evidence of chronic liver disease.
Conclusion
The diagnosis of extra hepatic portal venous obstruction and differentiation from
cirrhosis can be easily made by characteristic clinical features, normal liver function
tests and doppler ultrasound. Portal vein thrombosis (PVT) is the predominant cause
of extra hepatic portal vein obstruction in Nepali patients, as seen at this tertiary care
hospital in Nepal.
KEY WORDS
Cirrhosis, Extra hepatic portal vein obstruction, Thrombosis
Description
Sharma R,1 Pradhan B,1 Karki P,2 Bartaula B2
1Division of Gastroenterology and Internal Medicine
2Department of Internal Medicine
BP Koirala Institute of Health Sciences (BPKIHS),
Dharan, Nepal.
Keywords
Cirrhosis, Extra hepatic portal vein obstruction, Thrombosis