Publication: Sertoli Leydig Cell Tumour Initially Misdiagnosed as Polycystic Ovarian Syndrome and Congenital Adrenal Hyperplasia: A Case Report
Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Medical Association
Abstract
Abstract:
Sertoli-Leydig cell tumor of the ovary is an unusual neoplasm that belongs to a group of sex cord-stromal tumors of the ovary and accounts for less than 0.5% of all primary ovarian neoplasms. They are often characterized by the presence of mass with androgen production and signs of virilization. Due to the substantially low incidence of Sertoli-Leydig cell tumors, information on clinical behavior, prognostic factors, and optimal management arelimited. Here in, we report a case of aprimary ovarian Sertoli-Leydig cell tumor in a 21-year-old student, previously diagnosed to have polycystic ovarian syndrome and subsequently congenital adrenal hyperplasia, who presented with a large abdominal mass and features of virilization along with elevated serum testosterone levels. Fertility sparing unilateral salpingo-oophorectomy was done and adjuvant chemotherapy was given after histopathology showed moderate to poorly differentiated Sertoli-Leydig cell tumor. Following surgery, her features of hyperandrogenism resolved and serum testosterone levels returned to normal.
Description
Pooja Paudyal
Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital (TUTH), Maharajgunj, Kathmandu, Nepal
https://orcid.org/0000-0002-7522-0759
Geeta Gurung
Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital (TUTH), Maharajgunj, Kathmandu, Nepal
Josie Baral
Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital (TUTH), Maharajgunj, Kathmandu, Nepal
Nisha Kharel
Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital (TUTH), Maharajgunj, Kathmandu, Nepal
Keywords
hyperandrogenism, Sertoli-Leydig cell tumor, tumor differentiation