Publication: Low Cluster of Differentiation 4+ T Cell Count in People Living with HIV/AIDS Undergoing Antiretroviral Therapy Visiting a Reference Laboratory: A Descriptive Cross-sectional Study Authors
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Medical Association
Abstract
Abstract:
Introduction: Human Immunodeficiency Virus is a lentivirus that causes human immunodeficiency virus infection and over time, acquired immunodeficiency syndrome. Cluster of Differentiation 4+ T cell count of people living with this infection play a vital role to determine infection progression and necessary treatment changes. This study was conducted to find out the prevalence of low Cluster of Differentiation 4+ T Cell Count in the People Living with human immunodeficiency virus/ acquired immunodeficiency syndrome.
Methods: A descriptive cross-sectional study was conducted between June to August 2018 in the Human Immunodeficiency virus and Hepatitis Reference Unit of National Public Health Laboratory, Ministry of Health and Population Teku. Ethical approval was taken (Reference Number 2912) and a total of 550 seropositive cases of Human Immunodeficiency Virus-1 undergoing antiretroviral therapy were studied. Convenient sampling technique was used. Data was analysed by Statistical Package for the Social Sciences.
Results: Seventeen (3.1%) of patients had Cluster of Differentiation 4+ T cell counts below 100 cells/mm3 of blood. The mean Cluster of Differentiation 4+ T cell count was 509.3 cells/mm3 of blood. Of the total samples, 280 (50.9%) were males, 268 (48.7%) were females, and the rest 2 (0.4%) were of other gender.
Conclusions: Majority of people living with human immunodeficiency virus/ acquired immunodeficiency syndrome were found immune-competent.
Description
Samikshya Kandel
Nepal Academy of Science and Technology, Khumaltar, Lalitpur
Sundar Khadka
National Public Health Laboratory, Teku, Kathmandu, Nepal
Mahesh Lamsal
Department of Biotechnology, Tribhuwan University, Kirtipur, Kathmnadu, Nepal
Bimlesh Jha
National Public Health Laboratory, Teku, Kathmandu, Nepal
Sunil Paudyal
National Public Health Laboratory, Teku, Kathmandu, Nepal
Swotantra Gautam
B. P. Koirala Institute of Health Sciences, Dharan, Nepal
Sagar Poudel
All India Institute of Medical Sciences, New Delhi, India
Mukunda Sharma
National Public Health Laboratory, Teku, Kathmandu, Nepal
Jeena Amatya
St. Xavier’s College, Maitighar, Kathmandu, Nepal
Keywords
acquired immunodeficiency syndrome, cluster of differentiation 4 lymphocyte count, human immunodeficiency virus