Publication: A Prospective Observational Study on Use of Acute Physiology and Chronic Health Evaluation-II and Sequential Organ Failure Assessment Score to Predict Outcome
Date
2025
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Health Research Council
Abstract
Background: Acute physiology and chronic health evaluation –II (APACHE-II) and Sequential organ failure assessment (SOFA) is used to predict overall mortality and sepsis outcome in the intensive care unit (ICU) respectively. There are limited studies that have shown that both score can be used to predict mortality in surgical and medical patients admitted in the intensive care unit.
Methods: It was a prospective, observational study in a level three intensive care unit of National Medical College, Birgunj. This study was conducted in 542 patients admitted in the mixed intensive care unit of medical; college. Demographic data was gathered from each patient in the preformed sheet at the time of presentation to the intensive care unit. Outcome of patients was recorded in terms of mortality, discharge toward and leave against medical advice. The descriptive data are presented as the number and percentage for categorical data and mean ± standard deviation for continuous data according to their distribution
Results: Five hundred forty two patients were included in this study. 340(62.7%) were males and 202(37.3%) were females. 440(81%) patients survived and went home, 65(12%) expired, 26(5%) left the hospital against medical advice (LAMA) and 11(2%) gave do not resuscitate orders (DNR). The discrimination power was similar for APACHE II and SOFA scores (AUC=0.732 versus 0.771, respectively, p>0.05). APACHE II score>8.5 and SOFA >3.5 was cut off to predict mortality.
Conclusions: SOFA and APACHE II has similar discriminating power to predict mortality in all group of patients in a mixed intensive care unit.
Keywords: APACHE II; intensive care units; SOFA.
Description
Niraj Kumar Keyal
Department of General Practice and Emergency Medicine-Critical Care Medicine Unit, National Medical College, Birgunj, Nepal
https://orcid.org/0000-0001-8587-1718
Sudhakar Jha
Department of Internal Medicine, National Medical College, Birgunj, Nepal
Shahnaj Parween
Department of Anaesthesiology, National Medical College, Birgunj, Nepal
Ishfa Banu Haque
Department of Oral and Maxillofacial Surgery, National Academy of Medical Sciences, Bir Hospital
Tauqueer Ansari
Department of General Practice and Emergency Medicine-Critical Care Medicine Unit, National Medical College, Birgunj, Nepal
Istiyaque Ansari
Department of General Practice and Emergency Medicine-Critical Care Medicine Unit, National Medical College, Birgunj, Nepal.