Publication: A study of sensitivity and resistance of pathogenic micro organisms causing UTI in Kathmandu valley
Date
2005
Authors
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Journal ISSN
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Publisher
Kathmandu University
Abstract
A retrospective study was conducted in five hospitals to observe the prevalence of organisms causing UTI and their
sensitivity to antibiotics. Methodology: Altogether, data from five hundred samples of urine from five hospitals in
Kathmandu was collected for this study from January 2005 to April 2005. Result: A total of 244 samples were
found to be positive. Altogether six types of organisms were isolated as the causative factors. E. coli (49%), S.
aureus, (coagulase positive) (23%), Proteus species (3.6%), Klebsiella (9.71%), Pseudomonas (0.8%) and
Citrobacter (2.8%). Analysis of the samples showed that UTI was more common in females of younger age group as
comp ared to males. The common age group for females was 21-30 years, whereas that for males was 31-40 years in
all the hospitals except in hospital A, where the maximum number of females was from 31-40 years and males were
between 71-80 years. The most common organism to cause UTI was found to be E. coli (49%), followed by S.
aureus (23%) and Klebsiella (9.71%). All the organisms causing UTI were sensitive to nitrofurantoin and
amoxycillin and ciprofloxacin was found to be least effective. Similarly, in three hospitals, B (88.2%), D (64.7%)
and E (65.3%), amoxycillin was found to be most effective, amikacin and gentamycin (92.5%) was most effective in
hospital C, and nitrofurantoin in hospital A (78%). The second commonest organism, i.e., S. aureus (23%) was most
sensitive to cephalosporin (88.8%) of second generation, followed by nitrofurantoin (77.7%), amikacin (80.6%) and
norfloxacin (65.5%). The third common organism, Klebsiella (9.71%) was most sensitive to norfloxacin (75%) and
nitrofurantoin (75%). Lastly, Pseudomonas was resistant to all the antibiotics in hospital A, D and E, nil in hospital
B and sensitive to amikacin (100%) in hospital C.
Keywords: UTI, common pathogens, antibiotics sensitivity, resistance profile