Publication: Comparison of Oral Trichlophos and Intranasal Midazolam for Sedation in Minimally Invasive Paediatric Procedures (RAMT Study)
Date
2018
Article Type
Original Article
Journal Title
Journal ISSN
ISSN 1990-7974 eISSN 1990-7982
Volume Title
Pages
Pages: 80 - 83
Publisher
Nepal Paediatric Society (JNPS)
Abstract
Abstract:
Introduction: Uncooperative child does not allow completion of procedures, denying valuable data required for clinicians.
Material and Methods: An open labelled parallel group prospective randomized control study was conducted at zonal hospital Jorhat. We evaluated 200 children randomized into two groups using computer based randomization. Participants aged 3 months to 5 years (n=200) were randomized to receive 50 mg/kg Triclofos sodium orally or intranasal spray of midazolam 0.2 mg/kg.
Results: Adequate sedation (Ramsay reactivity score of 3 and 4) was obtained in 86% children in midazolam group as compared to 80% in triclofos group with p value of 0.138. Mean duration for onset of sedation was 20 min ± 5.4 min in Trichlophos group and 12 min ± 4.5 min with Intranasal Midazolam which was statistically significant with p-value of <0.001. The mean duration of post procedural sedation was found to be 24.00 ± 9.21 min in midazolam group and 49.00 ± 16.99 min in triclofos group (p=<0.001) which was statistically significant. No significant difference was seen for side effects frequency between the two drugs (15% in Triclofos, 10% in Midazolam group; p=0.285).
Conclusion: We conclude that intranasal midazolam is more effective than oral trichlophos with a comparable safety profile.
Description
Manoj Sharma
Military Hospital Jammu
Kamal K. Yenamandra
Command Hospital Air Force Bangalore, India
Jitu Kalita
7 Air Force Hospital Kanpur, India
Shaswat Dash
5 Air Force Hospital Jorhat, India
Daljit Singh
Command Hospital Air Force, Bangalore, India
Keywords
Trichlophos, Midazolam, Sedation, Ramsay score
Identifier
https://doi.org/10.3126/jnps.v38i2.19139