Publication: Comparison of Oral Trichlophos and Intranasal Midazolam for Sedation in Minimally Invasive Paediatric Procedures (RAMT Study)
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Paediatric Society (JNPS)
Abstract
Abstract:
Introduction: Uncooperative child does not allow completion of procedures, denying valuable data required for clinicians.
Material and Methods: An open labelled parallel group prospective randomized control study was conducted at zonal hospital Jorhat. We evaluated 200 children randomized into two groups using computer based randomization. Participants aged 3 months to 5 years (n=200) were randomized to receive 50 mg/kg Triclofos sodium orally or intranasal spray of midazolam 0.2 mg/kg.
Results: Adequate sedation (Ramsay reactivity score of 3 and 4) was obtained in 86% children in midazolam group as compared to 80% in triclofos group with p value of 0.138. Mean duration for onset of sedation was 20 min ± 5.4 min in Trichlophos group and 12 min ± 4.5 min with Intranasal Midazolam which was statistically significant with p-value of <0.001. The mean duration of post procedural sedation was found to be 24.00 ± 9.21 min in midazolam group and 49.00 ± 16.99 min in triclofos group (p=<0.001) which was statistically significant. No significant difference was seen for side effects frequency between the two drugs (15% in Triclofos, 10% in Midazolam group; p=0.285).
Conclusion: We conclude that intranasal midazolam is more effective than oral trichlophos with a comparable safety profile.
Description
Manoj Sharma
Military Hospital Jammu
Kamal K. Yenamandra
Command Hospital Air Force Bangalore, India
Jitu Kalita
7 Air Force Hospital Kanpur, India
Shaswat Dash
5 Air Force Hospital Jorhat, India
Daljit Singh
Command Hospital Air Force, Bangalore, India
Keywords
Trichlophos, Midazolam, Sedation, Ramsay score