Article: Effectiveness of Pyridostigmine and Pyridoxine in Vinca AlkaloidInduced Cranial Neuropathy – A Case Series
Abstract:
The neurotoxicity of the vinca alkaloids in the form of peripheral neuropathy is well known, however, cranial neuropathy is not widely recognized especially in children. We describe here in three children with malignancies who developed vinca alkaloid induced cranial nerve palsies during treatment which resolved on institution of pyridoxine and pyridostigmine. Vinca-alkaloid-induced cranial nerve palsies represent a potentially dangerous but reversible condition.
Aparajita Gupta
Department of Paediatrics, Command Hospital (EC), 17/1E, Alipore Rd, Alipore Police Line, Alipore, Kolkata, West Bengal 700027, India
Shuvendu Roy
Department of Paediatrics, Command Hospital (EC), 17/1E, Alipore Rd, Alipore Police Line, Alipore, Kolkata, West Bengal 700027, India
https://orcid.org/0000-0003-4095-8953
Prateep Paul
Department of Paediatrics, Command Hospital (EC), 17/1E, Alipore Rd, Alipore Police Line, Alipore, Kolkata, West Bengal 700027, India
Keywords
Neurotoxicity, Oncological urgency, Reversible Neuropathy
Identifier
https://doi.org/10.3126/jnps.v42i2.42865
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