Publication: Diagnostic Accuracy of Intraoperative Frozen Section in Ovarian Neoplasms: Experience in a Tertiary Oncology Centre
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Ovarian cancer is the second most common type of female genital tract malignancy.
Treatment planning differs for benign, borderline and malignant subtypes of
surface epithelial tumours and depends on accurate histopathological diagnosis.
A pre-operative diagnosis of the nature of ovarian tumors is not always reliable.
Frozen section is a valuable diagnostic tool in rapid intraoperative categorization of
ovarian masses and thereby helps in planning the surgical management. Adequate
management and treatment of ovarian carcinoma requires a complete surgical
staging supported by frozen-section examination. To achieve this goal it is necessary
to have a high level of accuracy.
Objective
To assess the accuracy of intra-operative frozen section in the diagnosis of various
categories of ovarian neoplasm conducted in Rajiv Gandhi Cancer Institute and
Research Centre.
Method
Intra-operative frozen sections for suspected ovarian neoplasm that underwent
surgery as primary line of therapy at this institution were analyzed retrospectively
from Jan. 2014 - Dec. 2015. The results of frozen section were compared with the final
histopathology diagnosis on paraffin sections and the overall accuracy, sensitivity,
specificity, positive and negative predictive values were determined.
Result
The study included 159 cases and the mean age of patients was 44.72±14.28 years
(Range 19-75 years). The mean size of tumor was 12.5±5.9 cm. Sensitivity of frozen
section for benign, borderline and malignant tumors was 98.53%, 73.33% and
94.74% respectively and the related specificities were 95.60%, 96.53% and 100%
respectively. There were 150 concordant cases and 9 discordant cases. Overall
diagnostic accuracy of frozen section was 94.33%.
Conclusion
Intra-operative frozen section diagnosis appeared to be an accurate and comparable
technique for the histopathology diagnosis of ovarian tumors.
KEY WORDS
Accuracy, Frozen section, Ovarian neoplasm, Sensitivity
Description
Bajracharya Shakya A,1 Jain V,2 Sekhon R,2 Rawal S,3 Mehta A4
Department of Gynae-Oncology
Nepal Cancer Hospital and Research Centre
Harisidhhi, Lalitpur.
2Department of Gynae-Oncology
3Department of Uro-gyneoncology
4Department of Patholgy
Rajiv Cancer Hospital and Research Centre,
Delhi.
Keywords
Accuracy, Frozen section, Ovarian neoplasm, Sensitivity