Publication: Nitrobenzene Induced Methemoglobinemia with Paroxysmal Atrial Fibrillation Treated with Single Volume Exchange Transfusions
Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Methemoglobinemia is a potentially fatal condition if left untreated. Conventional
treatment of nitrobenzene induced methemoglobinemia dictates the use of
methylene blue, which is the antidote of choice. However, its availability in our
setting is limited only to the laboratory use. We present a case of a 21-year-old
female with intentional ingestion of nitrobenzene. Clinical history and supportive
investigations revealed methemoglobinemia and it was successfully managed
with single volume exchange transfusions in absence of specific antidote. While
exchange transfusions are indicated for severe cases, it may be useful as an
alternative treatment in acute life-threatening conditions where methylene blue
is not available.
KEY WORDS
Exchange transfusion, Methylene blue, Nitrobenzene, Whole blood
Description
Sapkota P,1 Vaidhya N,1 Bhatt S,1 Shrestha P2
1Department of Internal Medicine
2Department of Public Health and Community Programs
Dhulikhel Hospital, Kathmandu University Hospital
Kathmandu University School of Medical Sciences
Dhulikhel, Kavre, Nepal
Keywords
Exchange transfusion, Methylene blue, Nitrobenzene, Whole blood