Publication: Lipid Profile and Ultrasonographic Grading in Alcoholic and Non Alcoholic Fatty Liver Patients
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Fatty liver disease (FLD) is a common and major chronic liver disease. It has been
implicated that patients have disorders of lipid metabolism and are involved in
the pathogenesis of fatty liver. Hence, it was designed to observe the association
between lipid profile and fatty liver disease.
Objective
This study was undertaken to evaluate the association of lipid profile status,
hemoglobin and albumin levels with fatty liver disease patients diagnosed based on
ultrasonography (USG).
Method
This Cross-sectional study was undertaken in the Department of Internal Medicine with
the collaboration of the Department of Radiology and Department of Biochemistry,
Universal College of Medical Sciences-Teaching Hospital (UCMS-TH), Bhairahawa,
Nepal from March 2019 to February 2020 in a total of 100 patients diagnosed with
fatty liver disease by ultrasonography. The fasting blood was collected for lipid profile
and carried out in the automated analyzer following standard protocol.
Result
In 100 cases, the male to female ratio was 1.8:1. Fifty six percent of the total cases
presented with alcoholic fatty liver disease (AFLD) while the remaining 44% with
nonalcoholic fatty liver disease (NAFLD). The spectrum of lipid abnormality was
observed with increased total cholesterol (TC), Low Density Lipoprotein (LDL),
increased triglycerides (TG), Very Low Density Lipoprotein (VLDL) in alcoholic fatty
liver disease cases as compared to nonalcoholic fatty liver disease cases. However, it
has been observed that TG/HDL and Non-HDL/HDL were higher in nonalcoholic fatty
liver disease as compared to alcoholic fatty liver disease. Moreover, a statistically
significant difference was observed in HDL between AFLG2 and NAFLG2 (p-value:
0.012).
Conclusion
Dyslipidemia and decreased HDL have been implicated in fatty liver diseases. USG in
conjunction with Non-HDL/HDL, TG/HDL, hemoglobin, and albumin can be useful in
early screening and monitoring of dyslipidemia in fatty liver patients.
KEY WORDS
Alcoholic fatty liver, Dyslipidemia, Non-alcoholic fatty liver
Description
Shahi A,1 Gautam N,2 Rawal S,3 Sharma U,4 Jayan A2
1Department of Internal Medicine
2Department of Biochemistry
3Department of Radiology
4B.Sc. MLT Student
Universal College of Medical Sciences,
Bhairahawa, Nepal
Keywords
Alcoholic fatty liver, Dyslipidemia, Non-alcoholic fatty liver