Publication: Diagnosis of Hemophagocytic Lymphohistiocytosis in Pyrexia of Unknown Origin: A Case Report
Date
2024
Article Type
Case Report
Journal Title
Journal ISSN
JNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
Volume Title
Pages
Pages: 401 - 403
Publisher
Nepal Medical Association
Abstract
Abstract
A case of a 61-year male presented with chief complaints of fever for three months. Diagnosis of hemophagocytic lymphohistiocytosis was made after liver biopsy when Positron-Emission Tomography revealed multiple fluoro deoxy glucose avid lesions in the liver. The patient of this disease typically presents with fever, splenomegaly, hyperferritinemia, hypertriglyceridemia, raised liver enzymes, and marrow features suggestive of hemophagocytosis. The treatment is usually systemic corticosteroids, chemotherapy with etoposide, cyclosporine, or hematopoietic stem cell transplantation, depending on the cause. A diagnosis like hemophagocytic lymphohistiocytosis can easily be missed in developing countries with low resources like Nepal. Hence, this disease should be suspected in patients presenting with pyrexia of unknown origin by treating physicians.
Description
Khusbu Thapa
Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal
Khusbu Thapa
Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal
Bikranta Bikram Kharel
Shreya Shrestha
Tanbir Ikram
Keywords
Identifier
https://doi.org/10.31729/jnma.8626