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Diagnosis of Hemophagocytic Lymphohistiocytosis in Pyrexia of Unknown Origin: A Case Report

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorThapa, Khusbu
dc.contributor.authorKharel, Bikranta Bikram
dc.contributor.authorShrestha, Shreya
dc.contributor.authorIkram, Tanbir
dc.date.accessioned2025-08-12T07:26:52Z
dc.date.available2025-08-12T07:26:52Z
dc.date.issued2024
dc.descriptionKhusbu Thapa Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal Khusbu Thapa Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal Bikranta Bikram Kharel Shreya Shrestha Tanbir Ikram
dc.description.abstractAbstract A case of a 61-year male presented with chief complaints of fever for three months. Diagnosis of hemophagocytic lymphohistiocytosis was made after liver biopsy when Positron-Emission Tomography revealed multiple fluoro deoxy glucose avid lesions in the liver. The patient of this disease typically presents with fever, splenomegaly, hyperferritinemia, hypertriglyceridemia, raised liver enzymes, and marrow features suggestive of hemophagocytosis. The treatment is usually systemic corticosteroids, chemotherapy with etoposide, cyclosporine, or hematopoietic stem cell transplantation, depending on the cause. A diagnosis like hemophagocytic lymphohistiocytosis can easily be missed in developing countries with low resources like Nepal. Hence, this disease should be suspected in patients presenting with pyrexia of unknown origin by treating physicians.
dc.identifierhttps://doi.org/10.31729/jnma.8626
dc.identifier.urihttps://hdl.handle.net/20.500.14572/1486
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.titleDiagnosis of Hemophagocytic Lymphohistiocytosis in Pyrexia of Unknown Origin: A Case Report
dc.typeOther
dspace.entity.typePublication
local.article.typeCase Report
oaire.citation.endPage403
oaire.citation.startPage401
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relation.isJournalIssueOfPublication.latestForDiscoveryd257200e-c055-409f-9801-b3821ec8b32c
relation.isJournalOfPublicatione6e146a0-0ece-4aba-aa0a-6ccfbd10a12a

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