Publication: Histopathological Analysis of Non-Neoplastic Superficial Lymphadenopathies
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Lymphadenopathies are the clinical manifestation of enlargement of lymph nodes
which are a common occurrence and are processes of lymph nodes in response to
a variety of exogenous and endogenous stimulants. The vast majority of enlarged
lymph nodes are non-neoplastic.
Objective
The objective of the study is to analyze the spectrum of non-neoplastic lesions of
superficial lymphadenopathies with their histomorphological features.
Method
This was a retrospective hospital based study done in the department of Pathology.
All cases of superficial lymph node biopsies received during a period of 7 years
were retrieved and divided into 2 broad categories: neoplastic and non-neoplastic.
The latter group is the material for the present study. The diagnosis was made on
morphological basis.
Result
Of all the 268 superficial lymph node biopsies, 25.4% (68 cases) were neoplastic
and 74.6% (200 cases) were non-neoplastic. The non-neoplastic cases were further
categorized into non-infectious 60.5% (121 cases) and infectious 39.5% (79 cases).
Neck node (70%) was the most common site of involvement. There were 102 male
and 98 female patients with male to female ratio 1.04:1. The age range of the patients
was 2 years to 83 years with a mean of 27.16 years and most common being 11-20
years 29% (58 cases). Majority of the cases were non-specific reactive lymphadenitis
84.3% (102 cases) followed by tuberculosis 36.5% (73 cases).
Conclusion
The major cause for the superficial lymphadenopathy was found to be non-
neoplastic etiology with slight male predominance. Reactive lymphadenitis was the
leading cause unlike the studies done in other Asian and Tropical countries where
tuberculosis was more common.
KEY WORDS
Lymphadenopathies, non-neoplastic, reactive lymphadenitis, tuberculosis
Description
Thapa S, Ghosh A, Ghartimagar D, Narasimhan R, Prasad T, Talwar OP
Department of Pathology
Manipal Teaching Hospital
Manipal College of Medical Sciences
Pokhara, Nepal
Keywords
Lymphadenopathies, non-neoplastic, reactive lymphadenitis, tuberculosis