Publication: Prevalence of Diastolic Dysfunction in Type 2 Diabetes Mellitus
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Diastolic dysfunction is an inability of the ventricle to fill to a normal end-diastolic
volume, both during exercise as well as at rest. Diabetes mellitus increases the risk of
heart failure even in the absence of other co-morbidities.
Objective
To find the prevalence of diastolic dysfunction in patients with type 2 diabetes
mellitus and its association with age, gender, duration, glycosylated hemoglobin
levels, dyslipidemia, tobacco smoking and alcohol consumption.
Method
Ninety patients with type 2 diabetes mellitus of both genders, aged 30 to 60 years,
were included in this study. Doppler echocardiography was performed to evaluate
diastolic dysfunction.
Result
The mean age of the study population was 46.21 ± 9.20 yrs. The overall prevalence of
diastolic dysfunction in the study population was 47.8%. The prevalence of diastolic
dysfunction increases with age: 23.1% in patients of age 30 – 39 yrs to 65.8% in
patients of age 50 – 60 yrs (adjusted OR 0.16, 95% CI 0.04 - 0.64, P = 0.010) and with
the duration of diabetes: 32.8% in patients with diabetes for <5 yrs to 75% in patients
with diabetes for >10 yrs (adjusted OR 0.31, 95% CI 0.08 - 1.00, P = 0.05). There
was no significant association between diastolic dysfunction and dyslipidaemia, BMI,
tobacco smoking, alcohol consumption, HbA1c and gender.
Conclusion
Prevalence of diastolic dysfunction in type 2 diabetes mellitus was 47.8% in our study.
A rising trend of prevalence of diastolic dysfunction with the duration of diabetes and
increasing age of patients was observed.
KEY WORDS
Diastolic dysfunction, Prevalence, Type 2 diabetes mellitus
Description
Yadava SK, Dolma N, Lamichhane G, Poudel N, Barakoti M, Karki DB
Department of Cardiology
Kathmandu Medical College Teaching Hospital
Kathmandu Nepal.
Keywords
Diastolic dysfunction, Prevalence, Type 2 diabetes mellitus