Publication: Isoniazid - induced chronic cutaneous Lupus erythematosus
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
Abstract
Abstract:
A 23-year-old man developed drug-induced chronic cutaneous lupus erythematosus 8 months after isoniazid (INH) therapy for pulmonary tuberculosis. Diagnosis was based on clinical aspects (discoid lesions on the face, erythema, photosensitivity, hyperpigmentation), histopathological examination, along with direct immunofluorescence examination (DIF), the absence of systemic involvement and the routine laboratory parameters, which registered all within normal range. Hydroxychloroquine therapy associated to photo protection and emollients determined the clear up of the facial eruption within six months. Transient residual hyperpigmentation could be noticed 2 months after discontinuation of the treatment. This case illustrates a rare form of drug-induced chronic cutaneous lupus erythematosus developed 2 months after withdrawal of antituberculosis therapy, with excellent results with hydroxychloroquine.
Keywords: Drug-induced chronic cutaneous lupus erythematosus, Isoniazid, Tuberculosis
Description
A Chiriac
Nicolina Medical Center, Iasi, Romania
P Brzezinski
Military Support Unit, Ustka
A E Chiriac
Department of Dermatology University of Medicine and Pharmacy "Gr. T. Popa" Iasi
L Foia
University of Medicine and Pharmacy "Gr. T. Popa" Iasi
D Mihaila
Department of Dermatology, University of Medicine and Pharmacy "Gr. T. Popa" Iasi
C Solovan
Department of Dermatology, University of Medicine V Babes, Timisoara