Publication: Intracranial Calcification and Seizure with Down Syndrome: A Case Report
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Medical Association
Abstract
Abstract
Down syndrome is a genetic disorder caused by an extra copy of chromosome number 21. New onset of seizure in adults with Down syndrome is rare. The exact pathogenesis of intracranial calcification and seizure in Down syndrome is unknown, however, a possible association between hypocalcemia and vitamin D deficiency in Down syndrome was reported. An 18-year-old girl with nasal bridge, mongoloid slants, clinodactyly and saddle gap of toes, and prominent Downs phenotypes was present with a low level of parathyroid hormone, calcium, and vitamin D. Due to a higher prevalence of intracranial calcification in people with Down syndrome, there is an increased possibility of hypocalcemia and vitamin D deficiency. Hence, serum levels of calcium and vitamin D should always be checked before starting treatment with anti-epileptic drugs.
Description
Authors
Nilshan Rai
KIST Medical College and Teaching Hospital, Gwarko, Lalitpur, Nepal
Monika Thapa
Department of Neurology, National Neuro Center, Maharajgunj, Kathmandu, Nepal
Merina Pokharel
Department of Neurology, National Neuro Center, Maharajgunj, Kathmandu, Nepal
Jinee Acharya
KIST Medical College and Teaching Hospital, Gwarko, Lalitpur, Nepal.
Dhirendra Yadav
Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal
Keywords
Basal ganglia, Down syndrome, Seizure, Trisomy 21