Publication: Role of Tranexamic acid in NSAIDS induced angioedema
Date
2023
Article Type
Case Report
Journal Title
Journal ISSN
ISSN 2822-1893 eISSN 2822-2016
Volume Title
Pages
Pages: 31 - 33
Publisher
Nepalese Respiratory Society
Abstract
Abstract:
Tranexamic acid (TXA) is an antifibrinolytic agent that inhibits the conversion of plasminogen to plasmin, a key step in kallikrein activation and bradykinin formation. Tranexamic acid is used in the prophylactic management of hereditary angioedema; however, evidence for TXA in Non-Steroidal Anti-inflammatory drug-induced angioedema (NSAIDS-AE) is limited. We describe a patient who presented to the ICU department with NSAIDS-AE and was successfully treated with TXA. This case suggests that TXA may be a beneficial treatment modality in the management of NSAIDS-AE and warrants further investigation.
Description
Rupak Chalise
Department of Critical Care Medicine, Nepal Mediciti Hospital
Saroj Poudel
Department of Critical Care Medicine, Nepal Mediciti Hospital
Manoj Bist
Department of Critical Care Medicine, Nepal Mediciti Hospital
Ashim Regmi
Department of Critical Care Medicine, Nepal Mediciti Hospital
Anup Ghimire
Department of Critical Care Medicine, Nepal Mediciti Hospital
Kishor Khanal
Department of Critical Care Medicine, Nepal Mediciti Hospital
Keywords
Anaphylaxis, Non-allergic Anaphylaxis, Tranexamic acid, Angioedema
Identifier
https://doi.org/10.3126/nrj.v2i1.59613