Publication: Evaluation of the Diagnostic Potential of Liver Aminotransferases and Alkaline Phosphatase in Patients with Cardiovascular Diseases
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Cardiovascular diseases (CVDs) are the major cause of morbidity and mortality,
particularly in developing countries. Early diagnosis with the best diagnostic marker
is highly desired for the prevention and timely treatment of CVDs. However, there is
still a dearth of an ideal marker for the detection of CVDs.
Objective
To explore the diagnostic potential of liver aminotransferases (AST and ALT), and
alkaline phosphatase for the diagnosis of CVDs without liver involvement.
Method
This was a cross-sectional study conducted among 200 adult patients with CVDs,
who visited the cardiology and emergency units of Manipal Teaching Hospital,
Pokhara, Nepal. The study was conducted from January 2018 to December 2020. The
baseline data on family history, anthropometry, baseline biochemical parameters,
liver enzymes, and cardiac biomarkers were collected using standard and validated
methods. The data were analyzed using SPSS version 21 and MedCalc software 2021.
Result
The diagnostic sensitivity of aspartate aminotransferase, alanine aminotransferase
and alkaline phosphatase were 53.7%, 52.6%, and 33.7% and specificity were 99%,
90%, and 90% respectively. The area under the curve (AUC) of AST, ALT, and ALP
were 0.78, 0.73, and 0.52 respectively. ROC curve indicated that serum AST and ALT
activity was a better reliable marker than the serum ALP activities.
Conclusion
Our study suggests that serum aspartate aminotransferase and alanine
aminotransferase but not alkaline phosphatase could have some diagnostic potential
to diagnose the risk of CVDs. However, they could not replace the currently adopted
cardiac biomarkers such as cTnI and CK-MB.
KEY WORDS
Alkaline phosphatase, Aminotransferases, Cardiovascular diseases, Diagnostic
potential
Description
Yadav NK,1,2 Pokharel DR,2 Kathayat G,2 Sigdel M,2 Hussain I1
1School of Life and Allied Health Sciences
Glocal University
Saharanpur, Uttar Pradesh, India
2Department of Biochemistry
Manipal College of Medical Sciences
Pokhara, Kaski, Nepal
Keywords
Alkaline phosphatase, Aminotransferases, Cardiovascular diseases, Diagnostic potential