Publication: Immune Responses in Neurodegenerative Diseases
Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Neurodegenerative disease is a progressive loss of neurons from central nervous
system and has a huge impact on health care system. Various causes have been
proposed of which inflammation has been suggested to be a probable key factor
in the most of such conditions. The involvement of immune cells including
lymphocytes in such diseased condition of the CNS supports this notion. The
effective therapy for these diseases has been sought for more than a half century
but still lacking such therapy. On such basis this review article has mainly focussed
on evidence of the involvement of immune cells in various neurodegenerative
diseases including Alzheimer’s disease, Parkinson’s diseases and Multiple sclerosis
and suggests a possible therapy of such diseased conditions of the CNS by the
modulation of immune system.
KEYWORDS
Alzheimer’s disease, lymphocytes, multiple sclerosis, neurodegenerative diseases,
parkinson’s disease, stroke, t cells
Description
Shrestha R,1 Shakya Shrestha S,1 Millington O,2 Brewer J,3 Bushell T2
1Department of Pharmacology
Dhulikhel Hospital - Kathmandu University Hospital
Kathmandu University School of Medical Sciences Dhulikhel, Nepal
2Strathclyde Institute of Pharmacy and Biomedical
Sciences, University of Strathclyde Glasgow, UK
3Institute of Infection, Immunity and Inflammation
College of Medical, Veterinary and Life Sciences
University of Glasgow, UK