Publication: Differential Hepatotoxic Effects of Sodium Valproate at Different Doses in Albino Rats
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Date
2018
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Liver plays an essential role for transforming and clearing chemicals that may cause
harmful effects to it. Sodium Valproate, renowned to be a potent antiepileptic
drug, when taken in overdose may cause toxic effects to liver and other organs as
well. Liver damage can be assessed with histological changes and measurement of
enzymes produced by it.
Objective
To investigate the histological changes induced by different doses of Sodium
Valproate ranging from 100-500 mg/kg/day and observe its correlation with liver
enzymes level in serum.
Method
Three-months old albino rats were divided into six groups, five in each. Control
group was treated with normal saline and rest five groups with Sodium Valproate
in different doses 100, 200, 300, 400 and 500 mg/kg/day respectively. Then, liver of
those experimented rats were examined histologically under the light microscope.
Furthermore, Liver enzymes; Alanine Transaminase and Aspartate transaminase
were measured to assess the micro-anatomical changes in liver.
Result
Distorted hepatic lobular architecture with aggregations of nuclei at certain interval
was observed in the groups of higher doses; 300 mg/kg/day and above. However,
accumulation of adipocytes was observed in all the Sodium Valproate treated rats
unlike the control group. When compared the enzyme levels among the groups, it
was found to be significantly increased in dose dependent manner. Besides, it also
showed skin lesions in all rats treated with the dose 400 mg/kg/day and above.
Conclusion
Higher doses of Sodium Valproate; 300 mg/kg/day and above induces hepatotoxicity
and skin lesions in adult albino rats.
KEY WORDS
Hepatotoxicity, Liver enzymes, Sodium valproate
Description
Shakya R, Hoque MK, Sapkota AS, Gupta PK
Department of Anatomy
Kathmandu University School of Medical Sciences
Dhulikhel, Kavre, Nepal.
Keywords
Hepatotoxicity, Liver enzymes, Sodium valproate