Publication: Clinical Response to Amoxicillin among Children with Acute Suppurative Otitis Media
Date
2025
Article Type
Original Article
Journal Title
Journal ISSN
1999-6217
Volume Title
Pages
Pages: 263 - 268
Publisher
Nepal Health Research Council
Abstract
Abstract:
Background: Acute Suppurative Otitis Media(ASOM) is a very common disease of childhood caused by various bacteria and viruses. Amoxicillin is used as first line antibiotics in the community setting as well as hospital setting.
Methods: This is a hospital based prospective observational cross-sectional study. All cases of ASOM of patients under 14 years presenting to the Patan Hospital with duration of less than 6weeks were included in the study. Ear discharge was collected using sterile cotton swab using aseptic precautions and sent to the Department of Microbiology for further processing. The children were treated with amoxicillin (80mg/kg/day) with maximum dose not exceeding 3g/day and follow up was done after 1 week of antibiotic therapy for clinical responsiveness.
Results: Out of 32 cases, 13 cases showed no growth of organism in the culture sensitivity reports. Among remaining 19 cases, 9 were sensitive and 10 were resistant to amoxicillin. Coagulase negative Staphylococcus (7) was the most common organism grown in the laboratory followed by Staphylococcus aureus (4) and Klebsiella pneumoniae (4). Chloramphenicol, linezolid, clindamycin and trimethoprim-sulphamethoxazole were the most common antibiotics sensitive to the organisms grown besides amoxicillin. Out of total 32 patients, 31 were responsive to high dose amoxicillin at the end of 1 week.
Conclusions: Oral amoxicillin in high doses is effective in the treatment of ASOM in children.
Description
Deepa Joshi
Department of ENT and HNS, Bir hospital, NAMS, Kathmandu.
Ajit Nepal
Department of ENT and HNS, Patan Academy of Health Sciences, Lalitpur, Nepal.
Namita Shrestha
Department of ENT and HNS, Patan Academy of Health Sciences, Lalitpur, Nepal.
Piyush Rajbhandari
Department of Microbiology, Patan Academy of Health Sciences, Lalitpur, Nepal.
Gyanendra Bagale
Department of ENT and HNS, Patan Academy of Health Sciences, Lalitpur, Nepal.
Saroj Chapagain
Department of ENT and HNS, Patan Academy of Health Sciences, Lalitpur, Nepal.
Srijana Dhakal
Department of ENT and HNS, Patan Academy of Health Sciences, Lalitpur, Nepal.
Keywords
ASOM, Cclinical response, High dose amoxicillin
Identifier
https://doi.org/10.33314/jnhrc.v23i02.4861