Publication: Less Invasive Surfactant Administration (LISA) in Premature Neonates, using 5F feeding tube versus 2 mm Endotracheal tube – An Innovative, Pilot study
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Paediatric Society (JNPS)
Abstract
Abstract:
Introduction: Administration of LISA using thin and soft catheters like 5 F orogastric tube, though less invasive, is technically challenging and needs expertise. We hypothesized, use of a 2 mm Endotracheal (ET) tube for administration of LISA could be an easy and convenient alternative.
Methods: This is a prospective, single-centric, quasi-random, pilot trial conducted in the inborn unit of a tertiary care hospital from May 2020 - December 2020. All the inborn preterm (28 - 34 weeks) neonates with respiratory distress requiring surfactant were alternately allocated to receive LISA using a 5 F infant feeding tube or an uncuffed 2.0 size ET tube. The primary outcome was successful administration of surfactant defined as a procedure without any need for positive pressure ventilation.
Results: In our study, 25 neonates were enrolled in each arm. Administration of LISA using 2 mm ET tube was associated with better success of surfactant administration with lesser incidence of PPV (20 vs 11, p < 0.05), desaturation (5 vs 12, p < 0.05), and bradycardia (3 vs 10, p < 0.05) compared to LISAOG.
Conclusions: Administration of LISA using a 2 mm ET is an easily adaptable and convenient alternative that is well tolerated by the neonates without any adverse effects.
Description
Kalyan Chakravarthy Konda
Niloufer Hospital, Osmania Medical College, Lakdikapool, Redhills, Hyderabad, Telangana, India.
Swapna Lingaldinna
Niloufer Hospital, Osmania Medical College, Lakdikapool, Redhills, Hyderabad, Telangana, India.
Sadiqua Anjum
Niloufer Hospital, Osmania Medical College, Lakdikapool, Redhills, Hyderabad, Telangana, India.
Madireddy Alimelu
Niloufer Hospital, Osmania Medical College, Lakdikapool, Redhills, Hyderabad, Telangana, India.
Himabindu Singh
Niloufer Hospital, Osmania Medical College, Lakdikapool, Redhills, Hyderabad, Telangana, India.
Apoorva Tadury
Niloufer Hospital, Osmania Medical College, Lakdikapool, Redhills, Hyderabad, Telangana, India.
Keywords
Endotracheal tube, Less invasive surfactant administration, preterm, Surfactant