Publication: A Comparative Efficacy and Adverse Clinical Events of Methotrexate versus Azathioprine with Steroid Mini Pulse Therapy in the Management of Moderate to Severe Alopecia Areata: A Tertiary Centre Based Interventional Study
| creativeworkseries.issn | ISSN 2091-0231 eISSN 2091-167X | |
| dc.contributor.author | Mishra, Aditi | |
| dc.contributor.author | KC, Shekhar | |
| dc.contributor.author | Shrestha, Elisha | |
| dc.contributor.author | Pandey, Chandranshu | |
| dc.contributor.author | Karn, Dharmendra | |
| dc.date.accessioned | 2025-09-23T09:22:10Z | |
| dc.date.available | 2025-09-23T09:22:10Z | |
| dc.date.issued | 2022 | |
| dc.description | Aditi Mishra Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal https://orcid.org/0000-0002-1758-2153 Shekhar KC Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal Elisha Shrestha Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal https://orcid.org/0000-0003-1337-7977 Chandranshu Pandey Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal Dharmendra Karn Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal | |
| dc.description.abstract | Abstract: Introduction: Alopecia areata is a T cell-mediated autoimmune disorder of hair follicles resulting in partial or total hair loss. Treatment of alopecia areata is difficult, and it has variable severity. Objectives: To compare the clinical efficacy and adverse clinical events of azathioprine versus methotrexate with steroid minipulse therapy in managing moderate to severe alopecia areata. Materials and Methods: Prospective non-blinded clinical trial conducted for 6 months in Department of Dermatology at Dhulikhel Hospital. Dermoscopic evidence of alopecia areata patients treated according to group assigned and effects and adverse event were noted. Results: There was a total of 36 patients enrolled. Twenty patients were in Group A (AZT+MPT) and 16 in group B (MTX+MPT). There was a significant improvement in SALT score at 6 months (Group A p-value: 0.03; group B p-value: 0.001). Treatment efficacy (percent scalp hair regrowth) in group A was 79.2%, and in group B was 89.01%. Conclusion: Both treatment regimens showed marked improvement with SALT score reduction; however, methotrexate with steroid minipulse therapy showed slightly higher treatment efficacy than azathioprine with steroid minipulse therapy. | |
| dc.identifier | https://doi.org/10.3126/njdvl.v20i1.42453 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/2293 | |
| dc.language.iso | en_US | |
| dc.publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) | |
| dc.subject | Alopecia areata | |
| dc.subject | Azathioprine | |
| dc.subject | Methotrexate | |
| dc.title | A Comparative Efficacy and Adverse Clinical Events of Methotrexate versus Azathioprine with Steroid Mini Pulse Therapy in the Management of Moderate to Severe Alopecia Areata: A Tertiary Centre Based Interventional Study | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 33 | |
| oaire.citation.startPage | 29 | |
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