Publication: A Comparative Efficacy and Adverse Clinical Events of Methotrexate versus Azathioprine with Steroid Mini Pulse Therapy in the Management of Moderate to Severe Alopecia Areata: A Tertiary Centre Based Interventional Study
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
Abstract
Abstract:
Introduction: Alopecia areata is a T cell-mediated autoimmune disorder of hair follicles resulting in partial or total hair loss. Treatment of alopecia areata is difficult, and it has variable severity.
Objectives: To compare the clinical efficacy and adverse clinical events of azathioprine versus methotrexate with steroid minipulse therapy in managing moderate to severe alopecia areata.
Materials and Methods: Prospective non-blinded clinical trial conducted for 6 months in Department of Dermatology at Dhulikhel Hospital. Dermoscopic evidence of alopecia areata patients treated according to group assigned and effects and adverse event were noted.
Results: There was a total of 36 patients enrolled. Twenty patients were in Group A (AZT+MPT) and 16 in group B (MTX+MPT). There was a significant improvement in SALT score at 6 months (Group A p-value: 0.03; group B p-value: 0.001). Treatment efficacy (percent scalp hair regrowth) in group A was 79.2%, and in group B was 89.01%.
Conclusion: Both treatment regimens showed marked improvement with SALT score reduction; however, methotrexate with steroid minipulse therapy showed slightly higher treatment efficacy than azathioprine with steroid minipulse therapy.
Description
Aditi Mishra
Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal
https://orcid.org/0000-0002-1758-2153
Shekhar KC
Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal
Elisha Shrestha
Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal
https://orcid.org/0000-0003-1337-7977
Chandranshu Pandey
Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal
Dharmendra Karn
Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal
Keywords
Alopecia areata, Azathioprine, Methotrexate