Publication: Serum iron Profile of Patients with Sickle Cell Disease and its Association with Socio-demographic Characteristics and Duration of Diagnosis
Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Health Research Council
Abstract
Abstract
Background : Sickle cell anemia is the most common hemoglobinopathy in the world. The study aimed to evaluate the iron profile and its association with socio-demographic characteristics in patients with sickle cell disease.
Methods: A hospital-based descriptive cross-sectional study was conducted to know the iron profile and its socio-demographic association in patients with sickle cell disease.
Results: The average serum iron, TIBC, and transferrin saturation were 16.75 ± 6.40 mcgMole/L, 69.46 ± 16.94 mcg/dl and 25.15 ± 12.51% respectively. The serum ferritin ranged from 10.00 to 3000.00 ng/ml. The proportion of participants with normal serum iron, TIBC, serum ferritin, and transferrin saturation were 86.10%, 0.00%, 33.90% and 36.40% respectively. All of the participants of this study had low TIBC (1005), and more than half of the participants had elevated serum ferritin (56.40%).
Conclusions: Iron overload is a common complication of sickle cell disease. There was no association of age and sex with iron profile. The TIBC variation between the Chaudhary ethnic group compared to other ethnic groups signifies the ethnic role in the iron profile.
Keywords: Ethnicity; iron overload; sickle cell disease; total iron binding capacity.
Description
Sher Bahadur Kamar
Department of Internal Medicine and COVID-19, Seti Provincial Hospital
Hemraj Pandey
Department of Paediatrics, Seti Provincial Hospital
Shurehraman Puri
Department of Emergency, Seti Provincial Hospital
Ramesh Shahi
Department of Pathology, Seti Provincial Hospital
Uttam Bhatta
Department of Internal Medicine, Seti Provincial Hospital,
Sulochana Khadka
Shree Birendra Sainik Hospital, Chhauni, Kathmandu, Nepal
Gopal Kumar Yadav
Department of Internal Medicine, Narayani Hospital, Birgunj
https://orcid.org/0000-0002-2195-9152
Prativa Subedi
Department of Internal Medicine, KIST Medical College and Teaching Hospital, Lalitpur, Nepal
https://orcid.org/0000-0001-9134-579X
Kapil Amgain
Department of Clinical Anatomy, Karnali Academy of Health Sciences
https://orcid.org/0000-0003-0887-6405