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Serum iron Profile of Patients with Sickle Cell Disease and its Association with Socio-demographic Characteristics and Duration of Diagnosis

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creativeworkseries.issn1999-6217
dc.contributor.authorKamar, Sher Bahadur
dc.contributor.authorPandey, Hemraj
dc.contributor.authorPuri, Shurehraman
dc.contributor.authorShahi, Ramesh
dc.contributor.authorBhatta, Uttam
dc.contributor.authorKhadka, Sulochana
dc.contributor.authorYadav, Gopal Kumar
dc.contributor.authorSubedi, Prativa
dc.contributor.authorAmgain, Kapil
dc.date.accessioned2025-08-01T07:09:20Z
dc.date.available2025-08-01T07:09:20Z
dc.date.issued2023
dc.descriptionSher Bahadur Kamar Department of Internal Medicine and COVID-19, Seti Provincial Hospital Hemraj Pandey Department of Paediatrics, Seti Provincial Hospital Shurehraman Puri Department of Emergency, Seti Provincial Hospital Ramesh Shahi Department of Pathology, Seti Provincial Hospital Uttam Bhatta Department of Internal Medicine, Seti Provincial Hospital, Sulochana Khadka Shree Birendra Sainik Hospital, Chhauni, Kathmandu, Nepal Gopal Kumar Yadav Department of Internal Medicine, Narayani Hospital, Birgunj https://orcid.org/0000-0002-2195-9152 Prativa Subedi Department of Internal Medicine, KIST Medical College and Teaching Hospital, Lalitpur, Nepal https://orcid.org/0000-0001-9134-579X Kapil Amgain Department of Clinical Anatomy, Karnali Academy of Health Sciences https://orcid.org/0000-0003-0887-6405
dc.description.abstractAbstract Background : Sickle cell anemia is the most common hemoglobinopathy in the world. The study aimed to evaluate the iron profile and its association with socio-demographic characteristics in patients with sickle cell disease. Methods: A hospital-based descriptive cross-sectional study was conducted to know the iron profile and its socio-demographic association in patients with sickle cell disease. Results: The average serum iron, TIBC, and transferrin saturation were 16.75 ± 6.40 mcgMole/L, 69.46 ± 16.94 mcg/dl and 25.15 ± 12.51% respectively. The serum ferritin ranged from 10.00 to 3000.00 ng/ml. The proportion of participants with normal serum iron, TIBC, serum ferritin, and transferrin saturation were 86.10%, 0.00%, 33.90% and 36.40% respectively. All of the participants of this study had low TIBC (1005), and more than half of the participants had elevated serum ferritin (56.40%). Conclusions: Iron overload is a common complication of sickle cell disease. There was no association of age and sex with iron profile. The TIBC variation between the Chaudhary ethnic group compared to other ethnic groups signifies the ethnic role in the iron profile. Keywords: Ethnicity; iron overload; sickle cell disease; total iron binding capacity.
dc.identifierhttps://doi.org/10.33314/jnhrc.v21i4.4716
dc.identifier.urihttps://hdl.handle.net/20.500.14572/1137
dc.language.isoen_US
dc.publisherNepal Health Research Council
dc.titleSerum iron Profile of Patients with Sickle Cell Disease and its Association with Socio-demographic Characteristics and Duration of Diagnosis
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage556
oaire.citation.startPage550
relation.isJournalIssueOfPublicationd5d1f27b-052b-4d4a-bce4-cd5f5f183f79
relation.isJournalIssueOfPublication.latestForDiscoveryd5d1f27b-052b-4d4a-bce4-cd5f5f183f79
relation.isJournalOfPublication40bd2739-8b19-447c-be60-723a1bdd1dcd

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