Publication: Platelet Count-to-platelet Distribution Width Ratio and other Platelet Indices as Cost-effective Markers of Preeclampsia: a case control study
Date
2024
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Platelet indices, like platelet count (PC), plateletcrite, mean platelet volume (MPV)
and platelet distribution width (PDW), and their ratios have shown to be cost-
effective and better predictors of preeclampsia (PE). However, platelet count/platelet
distribution width ratio was not studied.
Objective
To compare platelet indices and their ratios between pregnant women with and
without predictors of preeclampsia.
Method
An analytical, comparative, case-control study. Two groups were compared; pregnant
women with preeclampsia (case, n=24) and without preeclampsia (control, n=72).
Multivariable linear regression analysis for hematological parameters was performed
to assess the effect of gestational age. Logistic regression was performed to calculate
odds ratio. Receiver operating characteristic curve was used to determine sensitivity,
specificity and cutoff values. P < 0.05 was considered significant.
Result
There was statistically significant reduction in values of platelet count, plateletcrit,
platelet count/mean platelet volume, and platelet count/platelet distribution width
among the pregnant women with preeclampsia compared to control group, while
significant increase was noticed in platelet distribution width and mean platelet
volume. platelet count/platelet distribution width had the highest area under the
curve (AUC) of 0.767, followed by platelet distribution width (AUC=0.752). At the
cutoff of 15.1 (p<0.001) for platelet count/platelet distribution width, sensitivity
was 70.8%, and specificity was 81.9%. The odds of diagnosing true positive cases of
preeclampsia was 11.02 (95% CI =3.79-31.99, p=<0.001) times higher compared to
values below it at this cutoff.
Conclusion
Platelet indices are economical tests that can act as indicators of risk of preeclampsia.
Among these, platelet count/platelet distribution width has the highest sensitivity
and specificity in the detection of preeclampsia at the cutoff of 15.1 and has emerged
as better predictor of preeclampsia.
KEY WORDS
Platelet count, Platelet distribution width, Platelet indices, Preeclampsia
Description
Bashyal R,1 Singh A,2 Maharjan S,3 Tuladhar S,4 Bhattarai B,1 Sharma PK2
1Department of Biochemistry
2Department of Obstetrics and Gynecology
3Department of Physiology
4Department of Microbiology
Patan Academy of Health Sciences
Lagankhel, Lalitpur, Nepal
Keywords
Platelet count, Platelet distribution width, Platelet indices, Preeclampsia