Publication: Clinical profile and antibiotics response in typhoid fever
Date
2005
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Objective: The objective of this study is to evaluate the clinical profile and drug response in typhoid fever.
Methods: This is a retrospective analysis of paediatric patients suffering from typhoid fever who were admitted at
Kathmandu Medical College Teaching Hospital, Sinamangal during the period of two years and nine months.
Results: Total numbers of 100 cases of typhoid were studied. Diagnosis of Typhoid fever was based on clinical
features, Widal test and blood culture. The sensitivity pattern of drugs in blood culture was recorded. The mode of
presentation, treatment history, laboratory investigations reports, antibiotics administered and response to therapy
were recorded.
Conclusion: Quinolone is still the highly sensitive drug and most widely used for Salmonella typhi. Because of the
indiscriminate use of these drugs, resistant to ciprofloxacin has been quite high and the duration of the
defeverscence period has also been prolonged. But Ofloxacin is still showed highly effective and widely used with
good response.
Key words: clinical profile, antibiotics response, typhoid fever.