Publication: Analysis of Homocysteine Level in Patient with Acute Kidney Injury
Date
2025
Authors
Article Type
Original Article
Journal Title
Journal ISSN
1999-6217
Volume Title
Pages
Pages: 444 - 448
Publisher
Nepal Health Research Council
Abstract
Abstract:
Background: Homocysteine (Hcy) contributes to oxidative stress and renal injury by generating reactive oxygen species and reducing heme oxygenase-1 levels. Elevated Hcy (Hhcy) may worsen outcomes after acute renal failure(ARF), promoting fibrosis and progression to chronic kidney disease (CKD). This study investigates the association between Hcy levels and ARF in patients at Tribhuvan University Teaching Hospital.
Methods: This study was an analytical cross sectional single center study that was carried out in Tribhuvan University Teaching Hospital. Specimens were processed as per the guidelines of Standard Operating Procedure (SOP) of Biochemistry laboratory of Tribhuvan University Teaching Hospital.
Results: Participants had a mean age of 54.2 years. Mean homocysteine was (13.7±10.36) µmol/L and creatinine was (148.7±18.03) µmol/L. Homocysteine levels showed no significant association with age, sex, residence, or disease type. A weak but significant positive correlation was found between homocysteine and creatinine(r = 0.186, p = 0.029). Potassium correlated moderately with creatinine (r = 0.383, p< 0.001).
Conclusions: Homocysteine levels showed no significant association with age, gender, residence, or comorbid conditions. A weak but significant correlation was observed between homocysteine and creatinine, suggesting a potential link with renal function.
Description
Saroj Babu Aryal
Institute of Medicine, Clinical Biochemistry, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital
Deepak Raj Joshi
Institute of Medicine, Department of Community Medicine and Public Health , Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital
Keywords
Creatinine, Homocysteine, Potassium, Renal failure
Identifier
https://doi.org/10.33314/jnhrc.v23i03.4635