Publication: Clinico-Pathological Correlation of Colorectal Diseases by Colonoscopy and Biopsy
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Colonoscopy is a simple, safe and well tolerated procedure, the visualization of the
mucosa of the entire colon and terminal ileum to detect intestinal abnormalities and
obtain biopsy leads to the early detection of the pathologic process and institution
of appropriate therapy.
Objective
To find out the correlation between clinical and histopathological diagnosis of
colorectal diseases.
Method
A cross-sectional study was conducted at Department of Pathology, Dhulikhel
Hospital, Kathmandu University Hospital from Jan. 2015 - Jan. 2016. Altogether, 95
colonoscopic biopsies were examined and recorded clinical data using pre-designed
pro forma. The specimens were grossed, processed and embedded using standard
procedures, stained with Hematoxylin and Eosin stain and were analyzed using
light microscope. Special stains Ziehl Neelsen, and Periodic Acid-Schiff were used
whenever necessary.
Result
Analyses of 95 cases of colonoscopic biopsies were done. The most common
clinical diagnosis was polyp in 49 cases (51.57%) and the common histopathological
diagnosis was non-neoplastic polyps 31(32.63%). There was no correlation in cases
for suspected infectious colitis, microscopic colitis and hemorrhoids.
Conclusion
Colonoscopy is incomplete without biopsy and histopathology is the gold standard for
the diagnosis of colorectal lesions. The clinico-pathological correlation for neoplastic
lesions was excellent. However, correlation was poor in non-neoplastic lesion.
KEY WORDS
Colonoscopy, colorectal lesions, histopathology
Description
Makaju R,1 Amatya M,1 Sharma S,1 Dhakal R,1 Bhandari S,1 Shrestha S,1 Gurung R,2 Malla BR3
1Department of Pathology
2Department of Gastroscopy
3Department of Surgery
Dhulikhel Hospital, Kathmandu University Hospital
Dhulikhel, Kavre.
Keywords
Colonoscopy, colorectal lesions, histopathology